ウサギ鼻粘膜の電気的特性

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The water flow across the respiratory epithelia is an important determinant of the efficiency of mucociliary clearance. Bulk water flow has been shown to be coupled to net ion flux. We studied ion transport across rabbit nasal mucosa by measuring bioelectric properties using Ussing chambers. Results were summarized as follows.(1) Compared with tracheal mucosa, nasal mucosa exhibited lower potential difference (p<0.01), lower short-circuit current (p<0.05), and higher conductance (p<0.01).(2) Ouabain 10-4M inhibited short-circuit current when added to the submucosal bath of Ussing chambers, and amiloride decreased short-circuit current to about 40% when added to the mucosal bath.(3) When the bubbling of the solution was changed from 95% O2, 5% CO2 to 100% N2, shortcircuit current remarkedly decreased.(4) A significant positive correlation existed between temperature ranging from 33° to 41° and short-circuit current (r=0.46, p<0.02).
一般社団法人日本耳鼻咽喉科学会の論文