症例について (悪性変化した巨大な上顎形質細胞腫-1,2-)

概要

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Twenty cases of plasmacytoma have been reported in the Japanese otorhinolaryngological literatures. This case was a 61-year-old male with a large plasmacytoma spreading from the right maxillary sinus to nasal cavity.The hematologic and myelographic examination at admission revealed anemia in blood picture and plasma cell proliferation in the bone marrow picture. Now of patholcgical findings were observed in immune electrophoresis, serum protein fractions, serum Ca, etc. which were reported often to show characteristic changes in plasmacytoma.The prominent features of this case were the followings: (1) Although the plasmacytoma in the previous literatures was a benign, localized tumor, this case showed a shadow defect in the cranial bone which was believed to have either a malignant tumor with metastasis or a systematic disease of bone in a form of plasmacytomatous myeloma. (2) This case had failed to respond to 60Co irradiation and also to chemotherapy (Chromomycin A3 and Cyclophosphamide). (3) After the 60Co irradiation, malignant change to reticulosarcoma had taken place in the case, thus making this case a very rare one.
一般社団法人日本耳鼻咽喉科学会の論文