エピネフリン口蓋注射によるモルモットのショック死とその阻止について
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概要
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We, otorhinolaryngologists, often met with shock condition in surgical procedure of the pha- ryngical area, especially after local anesthesia in this area. A large number of studies have been carried on to get some informations on the factors of these shock conditions.Recently the hyperactivity of the autonomic nervous systems has been regarded as the important factor.On the other hand, we always use epinephrine for local anesthetics, which is a well-known stimulating drug of the sympathe- tic nervous system. The purpose of this experiments is to study the influence of epinephrine which injected into palate.Guinea pigs were used in these experi- ments. 1) 0.3cc of epinephrine was injected into the palate of guinea pigs.41.9% of them died within 30 minutes. 2) Same amount of epinephrine was injected subcutaneously.None of them died.This result indicates local speciality of the palate. 3) Same amount of epinephrine was injected intravenously(into, V.femoralis).About 80% of them died. 4) Same amount of epinephrine was injected into the palate of animals which were previously administered with chlorpromazine(1mg/kg).None of them died.This shows that the death due to epinephrine injection was completely prevented by chlorpromazine. 5) After Opium-Scopolamine(Inj.Alkaloid. Opii et Scopol.Ice) was administered, epinephrine was injected in the same way.The mortality of this group was 35.5%, and about a half of died injection of epinephrine. 6) On these experiments, histological findings of the lungs, livers, kidneys, and the adrenal glands were compared pathologically, and the peri- pheral circulatory failures induced by epinephrine were observed.
- 社団法人 日本耳鼻咽喉科学会の論文