耳中毒性薬物のモルモツト血管条および螺旋靱帯のATP水解系に対する影響について

概要

論文の詳細を見る
The present report is concerned with the pos- sible effects of various ototoxic drugs upon the enzymatic ATP-hydrolyzing system in the stria vascularis and spiral ligament of the guinea pigs which were intoxicated with these drugs by pa-renteral administration. The membrane ATPase, which is said to be closely related with the active transport of both sodium and potassium across the biological membranes, showed a decrease in com- parison to the normal cases, whereas the ouabain-insensitive componenent showed an increase. The ATP-hydrolyzing system as a whole did not yield any common results. The vestibular portion of the membranous labyrinth showed rather bizzare picture, so that no generalization of the changes was possible.
社団法人日本耳鼻咽喉科学会の論文