STUDIES ON VASCULAR PERMEABILITY AND MUCOSAL ABSORPTION IN THE FIELD OF OTO-RHINOLOGY:Part I Systemic Vascular permeability

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The author studied vascular permeability in healthy subjects and in those with various diseases accompanied with spontaneous nasal bleeding, using Landis' method. The Capillary Permeability Promoting Factor of Menkin was also studied at the same time. Results obtained were as follows:1) C.P.P factor level was variable even in healthy subjects.2) Vascular permeability for protein was far less variable compared with that for fluid.3) There was no direct relationship between vascular permeability and bleeding. Vascular permeability and vascular fragility were the characteristics not related each other.4) Vascular permeability for fluid was remarkably increased in those with spontaneous nasal bleeding and allergy. Vascular fragility was also increased in many cases.5) Vascular permeability and C.P.P factor were within normal limits even in the cases with leucemia and purpura in which bleeding tendency was prominent. Capillary fragility in these cases was remarkably increased.6) In cases with chronic sinusitis, fluid permeability was increased in many instances. After the surgery for sinusitis, C.P.P factor was elevated and fluid permeability was further increased. There was no change in C.P.P factor level in cases with simple hemorrhage and blood loss.7) Bleeding tendency observed clinically was related to fragility of the capillaries.
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