口腔の真菌検出率について

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概要

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• Deep-seated submucous Candididiasis of the mouth and pharynx is calling attention of the Otochino-laryngologist. because this disease shows strong resistance to any treatment.The author and co-operators are studying on this disease and had investigated distribution of Candida myces in the mouth of the patients without Candidiasis as a part of their study.The investigation was done randomly selected 200 patients, 100 out-patients and 100 in-patients admitted to Nagasaki University Hospital.72 strains of fungi were found from specimens of these patients (30%). As for the identification of Candida the slide aggultination test which was developed by Prof. Tsuchiya was employed.Among these cultured fungi C. albicans was identified in 42 strains (30% of all fungi cultured), C. parakrusei in 6, C. tropicalis in 5, C. krusei in 2, Cryptoccus and Aspergillus each in 2 strains. 13 strains of fungi were not classified.Fungi were identified from the mouth of the admitted inpatients in 46%, higher than in that of the out-patients.Patients of malignants with caries teeth and prothesis revealed the highest incidence of 65.5%.In the first decade of life fungi were cultured more frequently than in the fourth decade.Further more, the relationship between the distribution of Candida myces and administration of antibiotics was investigated.More Candida was cultured from the patients who were treated with the large dose of antibiotics than from the patients with minum chemotherapy.Achromycin was given experimentally to 20 patient for 2 weeks and Candida cultivation was carried out. As the results, catarrh stomatitis has occured in 80% of these patients, but Candida was identified only in 25% and the relationship between the dose of antibiotics and the incidence of Candida was not significant.Stomatitis with catarrh symptomes and occasionally associated with the brown or black coated tongue is not the manifestation of Candidiasis, such as acute and chronic thrush, and it is doubtfull of this type of stomatitis could be ascribed to Candida infection.

• 社団法人 日本耳鼻咽喉科学会の論文

著者

• 竹下 有二

  長崎大学医学部耳鼻咽喉科教室

• 竹下 有二

  長崎大学医学部耳鼻咽喉科学教室

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