内耳蝸牛の解糖呼吸系に関する研究

概要

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1) The oxygen consumption of the cochlea of guinea pigs were measured by means of Warbvrg's manometer, immediately after the cochlea were taken out.2) The cochleas were dissected under stereomicroscope without damage to their membranous structures. 3) Using glucose or succinate as the substrate, marked oxygen consumption of the cochleas was observed in vitro. 4) The oxygen consumption of the cochlea increased in Krebs Ringer solution and decreased in the high potassium media, when the cochlear structure was maintained and the endolymphatic space was closed. When the scala media was opened to substrate fluid, the change in oxygen consumption of the cochlea was revesed. 5) Cyanate influences the oxygen metabolism drogenase system was considered to be related with the activity of the cytochrome oxydase system.6) No Crabtreee effect was seen but the potassium effect was found to exist in the cochlea in the similar marmer as the brain tissue. 7) It was considered that the endolymph, in which potassium in high density is found, was useful in activating the production of biochemical energy in the cochlea.
社団法人日本耳鼻咽喉科学会の論文