内耳血流遮断時間と内リンパ電位の回復性に関する研究

概要

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The effect of local anoxia upon the endocochlear potential (EP) was examined by pressing the labrinthine artery for 10 to 120 minutes on 30 normal guinea pigs. The EP started to decline within a few seconds after cessation of the blood supply and the survival time (the time elapsed to reach 0mV)was 48.8±8.0 seconds. After the varying period of anoxia, the pressure was released to reestablish the blood suppy and the effect of re-oxygenation upon the EP was examined.In animals subjected to 10 to 20 minutes anoxia, the EP returned to the preischemic level by the release. When the duration of anoxia was 30 milnutes or longer, the recovery of the potential was incomplete and the duration of anoxia was directly related to the recovery of EP. In other words, the longer the duration of anoxia is, the lower the level of the EP after re-oxygenation.It should be noted that the EP showed the recovery to the level of+20 to 40 mV even after 120 minutes of anoxia. The possible role of transient anoxia on sudden deafness was discussed based on these results.
社団法人日本耳鼻咽喉科学会の論文