The Feasibility of Case-Control Studies Using Rezept Files of a Japanese Hospital : A Study on Thrombocytopenia
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A case-control study on thrombocytopenia with the Rezept files of Tokyo Medical and Dental University Hospital has been carried out. The study explored whether the case-control studies are feasible using files of Rezept system maintained in many Japanese hospitals for health insurance billing. Each of the 100 patients with thrombocytopenia was contrasted with one control case, matched for age, sex, in or out-patient, consultation clinic and year of registration. Of 1, 021 products of drugs registered in the files, 40 products (36 drugs) were associated with the disease. Through medical record review, low platelet count was confirmed in 94.6% of inpatients, while only in 26.9% of outpatients. Thirty-one cases of drug-induced thrombocytopenia were identified, and 29 suspected drugs were listed up. On the basis of the analysis of these data, we conclude that the Rezept files be useful in the case-control studies on adverse drug reactions similar to thrombocytopenia in inpatients. The medical records, however, must be reviewed to confirm the date of disease onset and to obtain information not included in the computerized data. J Epidemiol, 1994; 4 : 147-155.
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