Regression Analysis of Cancer Incidence Rates and Water Fluoride in the U.S.A. based on IACR/IARC (WHO) Data (1978-1992)

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概要

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• Age-specific and age-standardized rates (ASR) of registered cancers for nine communities in the U.S.A. (21.8 million inhabitants, mainly white) were obtained from IARC data (1978-82, 1983-87, 1988-92). The percentage of people supplied with "optimally" fluoridated drinking water (FD) obtained from the Fluoridation Census 1985, U.S.A. were used for regression analysis of incidence rates of cancers at thirty six sites (ICD-WHO, 1957). About two-thirds of sites of the body (ICD) were associated positively with FD, but negative associations were noted for lip cancer, melanoma of the skin, and cancers of the prostate and thyroid gland. In digestive organs the stomach showed only limited and small intestine no significant link. However, cancers of the oral cavity and pharynx, colon and rectum, hepato-biliary and urinary organs were positively associated with FD. This was also the case for bone cancers in male, in line with results of rat experiments. Brain tumors and T-cell system Hodgkins disease, Non-Hodgkin lymphoma, multiple myeloma, melanoma of the skin and monocytic leukaemia were also correlated with FD. Of the 36 sites, 23 were positively significant (63.9%), 9 not significant (25.0%) and 4 negatively significant (11.1%). This may indicate a complexity of mechanisms of action of fluoride in the body, especially in view of the coexising positive and negative correlations with the fluoridation index. The likelihood of fluoride acting as a genetic cause of cancer requires consideration.

• 日本疫学会の論文

著者

• Narita Kenichi

  Department Of Dentistry Smon Medical Center

• Takahashi Kosei

  Department Of Physical Medicine Faculty Of Medicine University Of Tokyo (formerly)

• AKINIWA Kenji

  Akiniwa Dental Clinic

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• Regression Analysis of Cancer Incidence Rates and Water Fluoride in the U.S.A. based on IACR/IARC (WHO) Data (1978-1992)
• Balneotherapy for Hypertension with Special Reference to the Factor Analysis of the Effects of Spa Treatment on Hypertensive Patients

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