Long-term Blood Pressure Variability and Cerebrovascular Changes on CT in a Community-based Elderly Population.
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概要
- 論文の詳細を見る
The effects of long-term blood pressure (BP) levels on cerebrovascular changes were analyzed in a community-based healthy elderly population. Cranial computed tomography (CT) was performed for 300 residents aged 69 years and older. Long-term BP during the ten years prior to CT was assessed, and the cerebrovascular changes were compared among different patterns of long-term blood pressure variability. White matter lesions (WML) and/or silent infarctions (SI) were found in 73 subjects (23.6%). Multiple logistic regression analysis showed that subjects with long-term diastolic hypertension (DHT) had the highest risk of cerebrovascular changes (adjusted odds ratio (OR), 95% confidence interval (CI); 7.1, 2.4-21.6, for WML; 7.2, 2.7-19.4, for SI), and that long-term isolated systolic hypertension (ISHT) was significantly associated with SI (adjusted OR, 95%Cl, 2.3, 1.1-4.9), but not with WML (adjusted OR, 95%CI, 1.3, 0.5-3.3). Efforts to prevent both DHT and ISHT would be beneficial, though different underlying mechanisms for WML and SI were suggested.J Epidemiol, 2001 ; 11 : 190-198
- 日本疫学会の論文
著者
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Kishi Reiko
Department Of Public Health Hokkaido University Graduate School Of Medicine
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Ying-yan Gong
Department Of Public Health Hokkaido University Graduate School Of Medicine
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Kobashi Gen
Department Of Health For Senior Citizens Hokkaido University Graduate School Of Medicine
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Tsukishima Eri
Department Of Neurology Hokkaido University School Of Medicine
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Kondo Kiyotaro
Department Of Public Health Hokkaido University
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SUGIMURA Iwao
The Director of Asahikawa Kosei General Hospital
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Saito Hiroya
Department Of General Surgery Chiba University Graduate School Of Medicine
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Niino Minehisa
Department Of Health Examination Asahikawa Kosei General Hospital
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Shido Koichi
Department Of Public Health Hokkaido University Graduate School Of Medicine
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Kondo Kiyotaro
Department of Public Health, Hokkaido University Graduate School of Medicine
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