ヌクレオチド補酵素の構造と機能

概要

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The article briefly describes the recent progress on the molecular structure and the function of nucleotide coenzymes, especially nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD), which are relatively small molecules but play a very important role in the enzymatic reactions. The molecular conformation of NAD elucidated from several solution studies by NMR, fluorescence etc. do not fully correspond to that found in enzyme-NAD complex and even in NAD<SUP>+</SUP>·Li<SUP>+</SUP> crystal, whereas the crystal structure of FAD is still unknown at the moment, and most plausible molecular conformation of FAD is proposed by conformational analysis based on the structural data of riboflavin-adenine molecular complex.
日本結晶学会の論文