DMH誘発ラット大腸腫瘍の発生の増殖に及ぼす高脂肪食の影響

概要

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We examined the influence of high fat diet on the carcinogenesis of the colon cancer induced by DMH in the 2 groups of experiments as follows. Group I -DMH 20 mg/kg x 1+MF diet (n=12) DMH 20 mg/kg x 1+Wilgram diet (n=12) Group II -DMH 20 mg/kg/week x 3+MF diet (n=12) DMH 20 mg/kg/week x 3 +Wilgram diet (n= 12) Male Spraque-Dawley rats were used in the both groups. The rats were sacrificed after 28 weeks and the grossly recognized tumors together with the flat background mucosa were histologically studied, particularly by serial sections for the latter. It is interesting to note that atypical glands developped by injecting low dose of DMH although only a few grossly visible tumors were induced. The high fat diet (Wilgram) had no significant effect on the grossly recognized tumor, however, it had promoting effect on the development of atypical glands in the flat background mucosa. In addition, the grade of atypic was higher in the high fat group as compared with the control group (MF). It is concluded that the high fat diet has promoting effect on the development of atypical glands in the flat mucosa which could be a precursor of the grossly visible tumor in the experimental colon cancer model by DMH.
日本大腸肛門病学会の論文