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Two cases of multiple adenomas associated with multiple early and advanced carcinomas of large bowl were reported.<BR>A 71-year old female received total colectomy and ileo-rectal anastomosis because of sigmoid and ascending colon cancer. Histologic examination of the resected specimen revealed advanced adenocarcinoma of sigmoid and ascending colon, 5 early carcinomas confined to the mucosa associated with 19 adenomas and a metaplastic polyp through out the colon. Step serial sections of the whole resected specimen revealed 2 microadenomas on the flat mucosa. A 76-year old male received sigmoid colectomy because of sigmoid cancer. Histologic examination of the resected specimen revealed 2 advanced carcinoma of sigmoid, 18 early carcinomas (2 invasive and 16 carcinomas confined to the mucosa) associated with 24 adenomas. Step serial sections of the whole resected specimen also revealed 15 microadenomas on the flat mucosa.<BR>Both patients have no family history in regards to adenomatosis coli, but association of multiple early and advanced carcinomas is striking. Although the nature of this type of multiple adenomas is not clear, it is suggested that these patients should be managed as those with adenomatosis coli.
日本大腸肛門病学会の論文