4. Histological Study on Adenoma-Early Cancer Relationship of the Large Bowel

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Adenoma-early cancer relatiotship was studied from the histological investigation of a large number of adenomas and carcinomas arising in adenomas of the large bowel. It was strongly suggested that the majority of colonic cancers evolved from preexisting adenomas. The concept was supported by the evidence that most focal cancers (carcinoma confined to the mucosa) were found in otherwise benign adenomas. It was also suggested that as cancers spread through the bowel wall so they expand on the mucosal surface and tend to destroy surviving benign adenomatous tissue. The process of malignant transformation in an adenoma may be variable in individual adenomas.<BR>Out of 100 adenomas removed through colonosope there were 18 early cancers, among which 16 cancers had definite histological evidence of adenoma origin. The value of colonoscopic polypectomy was emphasized in the treatment of colorectal polyps and in the study of adenomacancer sequence.