自家組織侵入型超極細ポリエステル繊維人工気管に関する研究
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The efficacy of high-porosity tracheal prostheses made of ordinary (12 μm in diameter) and ultrafine (3.7 μm) polyester fibers (SS-grafts) was investigated in rabbits.<BR>SS-grafts, 7 or 7.5 mm in inner diameter, previously reinforced with polypropylene fibers were implanted into the subcutis of rabbits, together with support tubing inserted into their lumina. The grafts were removed 3 weeks (group A) or 6 to 9 weeks (group B) after implantation. Histological examination showed that granulation tissue in the grafts in group B was more evenly distributed throughout the entire graft and had a more well developed vascular metwork than did that in group A.<BR>One-to 1.5-cm-long vascularized grafts in both groups were then transplanted from the subcutis into the cervical trachea of the same hosts. All 3 rabbits in group A were sacrificed 3 to 4 weeks after the operation because of evident stridor and labored breathing. The grafts showed marked destruction and stenosis due to abscess formation. In group B, 4 of 8 rabbits survived more than 4 weeks without respiratory symptoms, one was sacrificed because of moderate stridor at 3 weeks and the other 3 died of severe diarrhea or perforation of gastric ulcer. The grafts 4 weeks after replacement had columnar mucociliary epithelium throughout the grafts without stenotic changes in the lumina. These results indicate that SS-grafts that have been previously well vascularized readily undergo epithelialization and are infectionresistant. These prostheses seem to be useful for circumferential replacement of defects in rabbit tracheas.
- 特定非営利活動法人 日本呼吸器外科学会の論文
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- 自家組織侵入型超極細ポリエステル繊維人工気管に関する研究