Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome.

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概要

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• We measured myeloperoxidase (MPO), thiobarbituric acid reactive material (TBARM), and Type IV collagen 7S domain (7S collagen) in the plasma of 21 patients with acute lung injury (ALI). Sixteen healthy subjects served as a control group. There was no significant difference in MPO between the control and ALI groups. The TBARM and 7S collagen concentrations in ALI (TBARM; 3.05±0.65 nMol/ml, 7S collagen 9.06±5.96 ng/ml: Mean±SD) were significantly higher than those in the control group (2.54±0.33 and 3.43±1.05, p<0.05). TBARM and 7S collagen levels of deceased ALI patients were higher than those of surviving ALI patients (p<0.05). There were significant correlations between the plasma levels of these two parameters and the lung injury scores. Our findings suggest that plasma TBARM and 7S collagen are useful markers for the assessment of the severity of ARDS.(Internal Medicine 33: 257-262, 1994)

• 社団法人　日本内科学会の論文

著者

• Terashima Takeshi

  The Department Of Internal Medicine Ichikawa General Hospital Tokyo Dental College

• Kanazawa Minoru

  The Department Of Medicine School Of Medicine Keio University

• TASAKA Sadatomo

  The Department of Medicine, School of Medicine, Keio University

• URANO Tetsuya

  The Department of Medicine, School of Medicine, Keio University

• SAKAMAKI Fumio

  The Department of Medicine, School of Medicine, Keio University

• ISHIZAKA Akitoshi

  The Department of Medicine, Kawasaki City Ida Hospital

• HASEGAWA Naoki

  The Department of Medicine, School of Medicine, Keio University

• SAYAMA Kohichi

  The Department of Medicine, School of Medicine, Keio University

• NAKAMURA Hidetoshi

  The Department of Medicine, School of Medicine, Keio University

• WAKI Yasuhiro

  The Department of Medicine, School of Medicine, Keio University

• FUJISHIMA Seitaro

  The Department of Medicine, School of Medicine, Keio University

• KAWASHIRO Takeo

  The Department of Medicine, National Higashi-Saitama Hospital

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• Treatment of Bronchorrhea by Corticosteroids in a Case of Bronchioloalveolar Carcinoma Producing CA19-9.
• Clinical Significance of Measuring Myeloperoxidase, Thiobarbituric Acid Reactive Material and 7S Collagen in Plasma of Patients with Adult Respiratory Distress Syndrome.
• The Role of Recombinant Human Tissue-Type Plasminogen Activator in the Treatment of Acute Pulmonary Thromboembolism
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