Effects of Insulin on the Electrocardiogram

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(1) After intravenous administration of insulin, serial observations of electrocardiograms with blood pressure, blood sugar, and serum potassium concentration were made and in order to clarify the underlying mechanisms of the resulting electrocardiographic changes, similar observations after administration of insulin together with infusion of KCl solution or with hexamethonium injection and after subcutaneous administration of adrenalin were also made.(2) Among the various electrocardiographic changes observed after insulin injection, flattening of the Twave was the most marked and frequent, and was closely related to the serum K level especially in the earlier part of each experiment. Moreover, the Twave changes were abolished partially or completely by KCl infusion.(3) In the cases with hypoglycemic reactions in the insulin experiment, time courses of the Twave height and serum K concentration seemed to follow uneven curves and hypopotassemia was severe and prolonged. From these results and the results of the adrenalin experiment and hexamethonium-insulin experiment, it was concluded that adrenalin released with hypoglycemic reactions contributed to the insulin-induced hypopotassemia in the later part of the insulin experiment.(4) In most cases with hypoglycemic reactions in the insulin experiment, maximal change in the Twave preceded that in serum K, which indicated that the Twave changes produced by insulin could not be explained by the hypopotassemia alone.(5) Nature of the Tvector changes after administration of insulin and mechanisms of the hypopotassemic action of adrenalin and insulin were discussed.
International Heart Journal刊行会の論文

Effects of Insulin on the Electrocardiogram

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