Response to Oral Corticosteroid in Patients with Chronic Obstructive Pulmonary Disease.

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概要

• 論文の詳細を見る

• We studied the effect of 30mg of prednisolone on 29 Japanese patients with chronic obstructive pulmonary disease (COPD). The mean value of the baseline forced expiratory volume in one second (FEV1 ; mean±SEM) was 1.14±0.12l (46.9±3.9% pred) and the FEV1 following the steroid trial was 1.30±0.12l (53.7±4.3% pred). Post-trial FEV1-baseline FEV1/predicted FEV1 was 6.8±1.9%. Five patients (17%) had more than a 15% increase in FEV1 as a percentage of predicted FEV1. Post-trial FEV1/baseline FEV1 was 117.3±4.3%, and 12 patients (41%) had more than a 20% increase in FEV1 after the trial. Acute bronchodilator response to β-agonist correlated positively with the response to corticosteroid. Baseline spirometries, blood eosinophil counts, serum IgE levels, sputum eosinophil counts, family history of asthma, and history of paroxysmal dyspnea did not vary across responders and non-responders. Patients with severe COPD should be treated to achieve the best possible pulmonary functions indicated by a steroid trial within the limit of acceptable levels of adverse effects.(Internal Medicine 31 : 1179-1184, 1992)

• 社団法人　日本内科学会の論文

著者

• NISHIMURA Koichi

  the Second Department of Internal Medicine, Chest Disease Research Institute, Kyoto University

• IZUMI Takateru

  the Second Department of Internal Medicine, Chest Disease Research Institute, Kyoto University

• KOYAMA Hiroshi

  the Second Department of Internal Medicine, Chest Disease Research Institute, Kyoto University

• MIO Tadashi

  the Second Department of Internal Medicine, Chest Disease Research Institute, Kyoto University

関連論文

• Response to Oral Corticosteroid in Patients with Chronic Obstructive Pulmonary Disease.

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