Effects of Some Coronary "Vasodilators" on Myocardial Catecholamine
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The effects of the so-called "Vasodilators" on adrenaline, noradrenaline and dopamine concentrations of the normal and the infarcted area of the dog left ventricular muscle were studied. Vasodilators used were theophylline ethylenediamine, Persantin, nitroglycerine, Segontin, Niamide and Nardil.(1) Niamide and Nardil which are MAO inhibitors, increased the myocardial catecholamine concentrations. Noradrenaline concentration of the infarcted area was greater than that of normal area after the administration of MAO inhibitors. However, the administration of a large dose of Nardil caused a decrease in myocardial adrenaline concentrations. This is a distinct contrast to the administration of a small dose of Nardil.(2) Segontin decreased the myocardial catecholamine concentration, especially noradrenaline concentrations of the infarcted area. This decrease was a sharp contrast to the increase in noradrenaline concentration after the administration of Nardil.(3) Nitroglycerine increased the myocardial concentration of noradrenaline and dopamine. However, the mechanism of nitroglycerine on the catecholamine metabolism remained to be investigated.(4) Theophylline ethylenediamine, Persantin did not seem to affect profoundly on the myocardial catecholamine concentration.
- International Heart Journal刊行会の論文
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