Elevated Plasma Homocysteine Concentrations Six Months after Gastroplasty in Morbidly Obese Subjects

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概要

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• Objective To investigate whether the increased homocysteine levels occur in the first 6 months postoperatively, when nutritional intake is the most inadequate and weight reduction is the most drastic. Patients and Methods Fasting glucose, insulin, lipoprotein, homocysteine, folic acid and vitamin B12 levels and oral glucose tolerance test (OGTT) were determined in 12 morbidly obese subjects (3 men and 9 women with a mean age of 31±3 years, mean±SEM) before, 6 and 12 months after banded gastroplasty. Results Gastroplasty resulted in significant weight loss, from 12±16 to 92±6 and 88±7 kgs, 6 and 12 months postoperatively (all p<0.001). Fasting plasma insulin and triglyceride concentrations, the ratio of total cholesterol to HDL cholesterol, glucose and insulin responses to OGTT, and the degree of insulin resistance as expressed by the Homeostasis model index decreased significantly (p<0.05-0.001) following gastroplasty. Fasting plasma homocysteine concentrations increased from 10.2±0.8 to 12.110.6 at 6 months (p=0.036) and 12.0±1.2 μmol/l at 12 months (p=0.040), respectively. Pooled plasma homocysteine levels were negatively correlated with serum folate concentrations (r=-0.42, p=0.013). However, serum folate and vitamin B12 levels did not change after gastroplasty, nor did the relation between the loss of body weight and increase in homocysteine levels. Conclusion We observed that elevated circulating homocysteine levels occurred as early as 6 months after gastroplasty despite improvement in carbohydrate and lipoprotein metabolism in morbidly obese Chinese subjects.(Internal Medicine 40: 584-588, 2001)

• 社団法人 日本内科学会の論文

著者

• Sheu Wayne

  Divisions Of Endocrinology And Metabolism

• Sheu Wayne

  Division Of Endocrinology And Metabolism Department Of Internal Medicine Taichung Veterans General H

• Wu Hurng-sheng

  General Surgery

• Lee Wen-jane

  Divisions Of Endocrinology And Metabolism

• Wang Chen-wen

  Divisions Of Endocrinology And Metabolism

• Wan Chu-jen

  Department Of Dietetics Taichung Veterans General Hospital Taichung; National Defense Medical Center

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• From casual blood pressure measurement to long-term blood pressure burden : better elucidation of the association between versatile blood pressures and cardiovascular events
• Elevated Plasma Homocysteine Concentrations Six Months after Gastroplasty in Morbidly Obese Subjects

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