Central Effect of Some Vasoactive Substances as Observed by the Cross-Circulation in the Dog

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概要

• 論文の詳細を見る

• The results obtained in this series of experiments do not support any evidence of specific, sensitive chemoreceptors existing in the CNS. The results appear to indicate that the effects of vasoactive drugs may be explained on the basis of alteration in blood supply to the vasomotor centers of the brain or alteration in blood pressure upon some type of baroreceptors, although one must take account of some surgical and chemi-cal influences in interpreting those results obtained in this type of experi-ments. The decrease or increase of blood supply to the structures directly associated with controlling activity of the cardiovascular system may give rise to elevation or reduction of systemic blood pressure.It is very interesting to note that the reflex changes in the systemic circulation is much more pronounced when the drug is applied into the head circulation where the internal carotid and occipital arteries are tem-porarily clamped than where the external carotid artery is clamped. This observation may suggest that the extracranial beds, as a whole, are more sensitive to vasoactive drug than the intracranial beds. When a vaso-constrictor is applied, the extracranial beds may constrict to a higher extent than the intracranial beds, in turn, causing an increase in the blood supply to the intracranial beds. As it were, the vasoconstrictor agent may squeeze the extracranial blood into the intracranial beds. Conversely, a vasodilator substance is likely to withdraw the blood from the intracranial beds, thus causing hypertensive reflex.

• International Heart Journal刊行会の論文

著者

• Kumagai Hiroshi

  Department Of Electrical Engineering Faculty Of Science And Technology Kelo University

• Kumagai H.

  Department of Pharmacology, Faculty of Medicine, University of Tokyo

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