Superior Efficacy of MMCP Regimen Compared with VMCP and MMPP Regimens in the Treatment of Multiple Myeloma
スポンサーリンク
概要
- 論文の詳細を見る
Objective A newly designed combination chemotherapy for multiple myeloma, MMCP [ranimustine (MCNU), melphalan (MPH), cyclophosphamide (CPM) and prednisolone (PSL)], was analyzed and compared with the results of our previous randomized trial of VMCP [vincristine, MPH, CPM and PSL] and MMPP [MCNU, MPH, procarbazine and PSL]. Methods MCNU (33.3 nig/m2, div) on day 1 and MPH (4 mg/m2, po), CPM (66.7 mg/m2, po) and PSL (30 mg/m2, po) from day 1 to 4, were administered. Each cycle was repeated every 3 weeks. Patients or materials From January 1991 until August 1995, 104 patients with multiple myeloma diagnosed at 10 hospitals of Nagoya Cooperative Study Group were enrolled. Results Of the 87 evaluable patients, partial response rate for MMCP was 65.5% and was significantly higher than that of VMCP (13/47=27.7%, p<0.0001) and that of MMPP (21/47=44.7%, p=0.0196). A plateau attainment was observed in 49.4%. The percentage of the patients who attained plateau was significantly increased in the MMCP arm than in the VMCP arm (19.1%, p=0.0017) but was not in comparison with that of MMPP arm (42.6%, p=0.6790). Patients treated with MMCP survived significantly longer than those treated with VMCP or MMPP (p=0.0009 by generalized Wilcoxon test, p=0.0023 by log-rank test) with median survival for MMCP being 31.6 months, for VMCP 22.5 months, and for MMPP 22.9 months. No significant differences were observed with respect to adverse effects among the three regimens. Conclusion The newly designed MMCP is a candidate as an induction chemotherapy for multiple myeloma.(Internal Medicine 41: 290-294, 2002)
- 社団法人 日本内科学会の論文
著者
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Soda Hisashi
Department Of Hematology Tokyo Metropolitan Komagome Hospital
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Soda Hisashi
Department Of Internal Medicine Isahaya Insurance General Hospital
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SAITO Hidehiko
The First Department of Internal Medicine,Nagoya University School of Medicine
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Kobayashi Masahide
Department Of Hematology Hamamatsu Medical Center
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Shimizu Kazuyuki
The Department Of Internal Medicine Nagoya City Higashi General Hospital
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Saito Hidehiko
The First Department Of Internal Medicine Nagoya University School Of Medicine
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Takeyama Hideo
The Department Of Internal Medicine Nagoya Ekisaikai Hopital
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Nitta Masakazu
The Second Department Of Internal Medicine Aichi Medical University
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MIZUNO Harumitsu
the Department of Hematology, Social Insurance Chukyo Hospital
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YAMAO Hisami
the Department of Hematology, Social Insurance Chukyo Hospital
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NAGURA Eiichi
the Department of Internal Medicine, Chubu National Hospital
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KAMIYA Osamu
the Department of Internal Medicine, Anjo Kosei Hospital
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WAKITA Atsushi
the Second Department of Internal Medicine, Medical School, Nagoya City University
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ICHIKAWA Atsushi
the Department of Hematology, Gifu Prefectural Tajimi Hospital
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KOBAYASHI Masahide
the Department of Hematology, Hamamatsu West Medical Center
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KAWASHIMA Kohei
the First Department of Internal Medicine, Nagoya University, School of Medicine
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NAGURA Eiichi
Division of Hematology, National Chubu Hospital
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KAMIYA Osamu
Anjo Kosei Hospital
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ICHIKAWA Atsushi
Tajimi Prefectural Hospital
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MIZUNO Harumitsu
Chukyo Hospital
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Kobayashi K
Department Of Hematology/oncology Osaka Medical Center And Research Institute For Maternal And Child
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Shimizu Kiyoshi
Department Of Physiology Institute Of Health Sciences Hiroshima University Faculty Of Medicine
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Shimizu Kanako
Research Unit For Cellular Immunotherapy And Research Unit For Therapeutic Model The Institute Of Ph
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Mizuno Hiromi
Department Of Otorhinolaryngology Yokohama City University School Of Medicine
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Yamao Hisami
The Department Of Hematology Social Insurance Chukyo Hospital
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Kamiya O
Akita Univ.
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Kamiya Osamu
The Department Of Internal Medicine Anjo Kosei Hospital
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Nagura Eiichi
The Department Of Internal Medicine Chubu National Hospital
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Wakita Atsushi
The Second Department Of Internal Medicine Medical School Nagoya City University
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Nitta Masakazu
Second Department Of Internal Medicine Aichi Medical University
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Shimizu K
Research Unit For Cellular Immunotherapy And Research Unit For Therapeutic Model The Institute Of Ph
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Suzuki Hideyoshi
Division Of Hematology Tokyo Metropolitan Komagome Hospital
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Ichikawa Atsushi
The Department Of Hematology Gifu Prefectural Tajimi Hospital
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Kobayashi Masahide
The Department Of Hematology Hamamatsu West Medical Center
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Mizuno Harumitsu
The Department Of Hematology Social Insurance Chukyo Hospital
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ICHIKAWA Atsushi
The Department of Hematological Oncology, Gifu Prefectural Tajimi Hospital
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