Attenuated release of atrial natriuretic factor due to sodium loading in salt-sensitive essential hypertension.

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Forty-one patients with essential hypertension were classified as saltsensitive (SS) or non-salt-sensitive (NSS) from the changes in mean blood pressure (MBP) with alterations in sodium intake from 35mmol (lowsodium) to 250mmol/day (high-sodium). Whereas there was no difference in plasma levels of atrial natriuretic factor (ANF) on a normalsodium diet (120mmol) between the 2 groups, the degree of increase in the plasma ANF level between the low- and high-sodium intake was significantly greater in NSS than in SS (p<0.001). In addition, the urinary sodium excretion on a high-sodium diet was smaller in SS than in NSS. There was a significant positive correlation between the plasma ANF and MBP after the high-sodium intake in both SS (r=0.67, p<0.01) and NSS (r=0.60, p<0.01); however, the relation of plasma ANF to MBP shifted apparently to a lower level in SS compared with NSS. These findings not only indicate that there exists a hyporesponsiveness of ANF release by the heart of SS patients in response to high-sodium loading, but also imply that such a response contributes to blood pressure-elevating mechanisms due to sodium loading in this type of human hypertension.
International Heart Journal刊行会の論文