Myocardial Metal Content in Patients Who Expired from Cyanotic Congenital Heart Disease and Acute Rheumatic Heart Disease
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概要
- 論文の詳細を見る
The importance of metals in normal and pathologic cardiovascular function has been recognized. Significant derangements in myocardial Ca2+, Mg2+, and Cu2+ have been reported in ischemic heart injury. We studied 3 groups of hearts: 1) fifteen specimens obtained from patients who had no heart disease, 2) nine specimens from patients who had expired from cyanotic congenital heart disease, and 3) ten specimens from patients who had expired from acute rheumatic heart disease with carditis and severe heart failure. None of the patients had undergone cardiac surgery. Left ventricular lateral wall Mg2+, Ca2+, Cu2+, and Zn2+ contents were measured by atomic absorption spectrometry. The results showed a significant decrease in myocardial Mg2+ (Group I 177.06±32.71; Group II 155.66±14.79; Group III 149.00±13.29, p<0.05 and p<0.01, respectively), and Cu2+ contents (Group I 3.22±0.37; Group II 2.94±0.22; Group III 2.56±0.32, p<0.02 and p<0.001, respectively), and a rise in myocardial Ca2+ content (Group I 36.06±10.72; Group II 43.22±7.01; Group III 46.30±4.85, p=not significant, and p<0.01, respectively). The myocardial Zn2+ content did not change significantly (Group I 26.53±3.99; Group II 26.00±4.15; Group III 26.40±3.53). The myocardial Mg2+/Ca2+ ratio was reduced markedly in both groups (Group I 5.328±1.879; Group II 3.685±0.735; Group III 3.135±0.291, p<0.001 for both Groups II and III vs Group I). The latter results correlated closely with the myocardial Mg2+/Ca2+ ratios reported in experimental models in peri-infarction zones. Thus, the myocardium of patients who had expired from cyanotic congenital heart disease and acute rheumatic carditis is jeopardized by ischemia, with metal contents similar to the border areas in myocardial infarction.
- International Heart Journal刊行会の論文
著者
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SHAKIBI Jami
Department of Pediatric Cardiology, the Cardiovascular Medical and Research Center, Heart Hospital
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NAZARIAN Iraj
Department of Pathology, Queen Pahlavi Cardiovascular Center
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MOEZZI Bahram
Departments of Biochemistry, Cardiovascular Medical and Research Center
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SHAKIBI Jami
Departments of Pediatric Cardiology, Cardiovascular Medical and Research Center
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SHAKIBI Jami
Department of Pediatric Cardiology the Cardiovascular Medical and Research Center
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NAZARIAN Iraj
Departements of Pathology and Pediatric Cardiology, Queen Pahlavi Foundation Cardiovascular Medical Center
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NAZARIAN Iraj
Departments of Pathology, Cardiovascular Medical and Research Center
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