A Study on Timed Intracellular Localization and Distribution of Tritiated Digitoxin and Proscillaridin A in the Myocardial Cells by Electron Microscopic Autoradiography

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概要

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• In order to analyse the mechanism of the positive inotropic effect on the myocardium of cardiac glycosides, the author studied on the timed localization and distribution in the rat myocardial cells of the glycosides by means of electron microscopic autoradiography.Since most part of the glycosides may be lost from the tissues during the process of fixation and dehydration, the methods were studied. The radioactivity in the tissue was measured by the oxygen combustion method. Little part of the glycosides was lost when the tissues were fixed with glutaraldehyde and osmium tetraoxide, and then dehydrated with acetone series.By this method the author found most silver grains distributed in the transverse system (T system), the sarcoplasmic reticulum and the sarcolemma. This may suggest that the glycosides act upon the membraneous component.

• International Heart Journal刊行会の論文

著者

• SATO Tomohide

  First Department of Internal Medicine, Faculty of Medicine, University of Tokyo

関連論文

• A Study on Timed Intracellular Localization and Distribution of Tritiated Digitoxin and Proscillaridin A in the Myocardial Cells by Electron Microscopic Autoradiography
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