Pantethineの生物学的研究(X) Pantethineの胃腸管運動亢進作用に対する麻酔薬の影響

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The intestinal motility-promoting effect of pantethine was examined in rabbits, dogs and mice under various anesthetic conditions. In rabbits (Trendelenburgs method), the effect was easily detectable when the animals were anesthetized with pentobarbital or urethane or immobilized with d-tubocurarine chloride, but not in the case of α-chloralose anesthesia. In dogs (balloon method), on the contrary, the effect was easier to be detected under α-chloralose anesthesia rather than urethane anesthesia. On the other hand, the promotive effect of pantethine on the passage of charcoal meal through mouse intestine could not be found under anesthesia with urethane or α-chloralose, though it was detectable under pentobarbital anesthesia. The effect of pantethine concerned was considered to be chlinergic as it was augmented by neostigmine and antagonized by atropine. The influence of anesthetics on the effects of pantothenic acid, neostigmine, carpronium chloride and bethanechol chloride have also been described.
社団法人日本薬理学会の論文