Alcohol類兎皮内注射による局所毛細血管透過性亢進

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The increased capillary permeability (and non-blued area) produced by the intracutaneous injection of alcohols in rabbits were investigated. 1) The ch ange of permeability by dihydric alcohols (C2 to C6) were proportional to the length of their carbon chain. 2) The increased permeability and the size of non-blued area were inversely proportional to the numbers of hydroxyl residue in lower alcohols. 3) There were not or scarcely differences among the responses formed by some position isomers of dihydric alcohols. 4) Polyoxyethylene glycols of various molecular weights at a constant molar concentration leaded the indistinguishable extents of the increased permeability, and a similar relationship was found in the formation of non-blued area by these glycols at a same concentration in percent. 5) The pretreatment of diphen hydramine inhibited partialy the increase of permeability by lower alcohols, but not those by higher alcohols. 6) The increse of permeability by alcohols was not effected by the pretreatment of salicylate, glycyrrhizin and cortisone. 7) The change of permeability by alcohols seemed to be related with their oil-water partition coefficient and their surface activity. 8) The mechanisms on local action of alcohols were discussed from the results in previous and this papers.
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