有機リン剤Ethyl-p-nitrophenyl phenylphosphonothioate(EPN)のTryptophan Pyrrolase活性におよぼす影響ならびに血中Cholinesterase値および縮瞳の関連について

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Correlation between cholinesterase (ChE) inhibition, miosis and tryptophan pyrrolase (TP) activity in EPN-treated rats was investigated, and following results were obtained. 1) Inhibit ion of serum ChE was initiated at 1h and continued untill 24h after EPN administration, however, maximum response of miosis and increase in TP activity were observed 6h after treatment and gradually recovered to initial levels within 24h. These observations indicated that ChE inhibition was evoked prior to changes in pupil reaction and TP activity. 2) Increase in TP activity was inhibited by pretreatment with either β-adrenergic blockers, propranolol and DCI or atropine and PAM, moreover, adrenalectomy abolished completely the increase in TP activity. It is likely, therefore, that administration of EPN did stimulate the secretion of glucocorticoid from adrenals through autonomic nervous system.
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