Norbormideの薬理作用

概要

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Norbormide, [5-(α-hydroxy-α-2 pyridylbenzyl)-7-(α-2 pyridylbenzylidene)-5-norbornene-2, 3-dicarboximide] is selectively toxic to the genus Rattus and its LD<SUB>50</SUB> iss 5-10 mg/kg. It dose not produce significant changes in species other than the rat and its LD<SUB>50</SUB> are more than 1 g/kg. Norbormide caused elevation of blood pressure in rats at the dose less than 1 mg/kg, while caused fall of blood pressure in dogs and rabbits at the dose of 10 mg/kg. The cause of death in rat by Norbormide are significat constriction and loss of tension of wall of peripheral blood vessels in organs.
社団法人日本薬理学会の論文