2,3-Dimercaptopropanolによる蛙皮膚黒色化と蛙皮膚のSerotoninとの関係について

概要

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An injection of 2, 3-Dimercaptopropanol (BAL) (0.5 mg/10 g) into the abdominal lymphatic space induced a dispersion of the pigment in the melanocytes of the skin. In hypophysectomized frogs, however, BAL failed to induce the dispersion. A large amount of indolealkylamines, especially serotonin, was found in the skinof <I>Rana nigromaculata</I> (56.7 μg/g in the skin of frogs collected during autamun).Although seasonal variations were found in the serotonin level of the frog skin, BAL invariably decreased the serotonin level in each frog. In hypophysectomized frogs, however, BAL failed to decrease the serotonin level. From the above results, it is assumed that there is a certain correlation between serotonin level and melanocyte dispersion in the skin of frogs.
社団法人日本薬理学会の論文