胸腺の系統間相互移植が鶏のマレック病抵抗性および免疫能力に及ぼす遺伝的効果〔英文〕

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The genetic effects of thymectomy and thymus transplantation on resistance to Marek's disease (MD) and immunocompetences were studied. Chicks from the IgG-H and IgG-L lines, selected for high and low levels of serum immunoglobulin G (IgG), were thymectomized and some of them were mutually transplanted with the thymus from those of the other line. One group of chicks was inoculated with the JM strain of MD virus and another group was examined for immunocompetences. MD incidence, MD mortality, graft-versus-host reaction (GVHR) competence and antibody titers to sheep red blood cells (SRBC) and Brucella abortus were compared among three groups; control, thymectomized and thymus transplanted. The IgG-L line was more resistant to MD than the IgG-H line. In the thymectomized groups, MD incidence and MD mortality increased in both lines. Mean days at MD incidence and MD death showed a decreasing trend. In the thymus transplanted groups, MD incidence and mortality were decreased in the IgG-H line which received thymus from the resistant L line and increased in the IgG-L line which received susceptible H line's thymus. A reverse trend was also observed in the mean days at MD incidence and MD death. The GVHR competence was little affected by thymectomy or thymus transplantation. Immune responses to SRBC and Brucella abortus were also not affected by thymectomy. However, thymus transplantation caused a significant decrease of MD resistance in the IgG-H line which received thymus from the IgG-L line, although almost no effect was observed in the IgG-L line which received the IgG-H thymus. It was suggested that MD resistance and immune response competence could be transferred by thymus grafting.
社団法人日本畜産学会の論文

胸腺の系統間相互移植が鶏のマレック病抵抗性および免疫能力に及ぼす遺伝的効果〔英文〕

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