A New Series of 2-Alkoxy(aralkoxy)-[1,2,4]triazolo[1,5-a]quinazolin-5-ones as Adenosine Receptor Antagonists
スポンサーリンク
概要
- 論文の詳細を見る
This research was carried out to study the pharmacological activity of a newly synthesized series of 2-alkoxy-[1,2,4]triazolo[1,5-a]quinazolin-5-ones as adenosine receptor antagonists. These compounds have been tested in radioligand binding assays on cloned Chinese hamster ovary (CHO) cells transfected with A1, A2A, A2B and A3 receptors. In particular, among the triazoloquinazolines (1—11), the dialkoxy derivative (7b) was found to have the highest affinity at A1 subtype receptor, and its radioligand binding activity together with 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was studied. Finally, the structure–activity relationship (SAR) studies on the titled compounds provide some new insights about steric hindrance and lipophilic requirements for anchoring to the adenosine receptors recognition site.
論文 | ランダム
- 翻訳 コルネイ・チュコーフスキイの日記より(2)
- 翻訳 ヴェチェスラフ・カザケーヴィチ『ロシア文学史』--「ロシアの心」の四季(6)
- 1P207 細菌べん毛特異的蛋白質輸送に関わるFliH-FliI複合体のX線結晶構造解析(細胞生物的課題(接着,運動,骨格,伝達,膜),第48回日本生物物理学会年会)
- 1P165 Na+駆動型べん毛モーターの回転速度の圧力依存性(分子モーター,第48回日本生物物理学会年会)
- 1P015 細菌べん毛フック繊維連結部の極低温電子顕微鏡による構造解析(蛋白質-構造,第48回日本生物物理学会年会)