A New Series of 2-Alkoxy(aralkoxy)-[1,2,4]triazolo[1,5-a]quinazolin-5-ones as Adenosine Receptor Antagonists
スポンサーリンク
概要
- 論文の詳細を見る
This research was carried out to study the pharmacological activity of a newly synthesized series of 2-alkoxy-[1,2,4]triazolo[1,5-a]quinazolin-5-ones as adenosine receptor antagonists. These compounds have been tested in radioligand binding assays on cloned Chinese hamster ovary (CHO) cells transfected with A1, A2A, A2B and A3 receptors. In particular, among the triazoloquinazolines (1—11), the dialkoxy derivative (7b) was found to have the highest affinity at A1 subtype receptor, and its radioligand binding activity together with 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was studied. Finally, the structure–activity relationship (SAR) studies on the titled compounds provide some new insights about steric hindrance and lipophilic requirements for anchoring to the adenosine receptors recognition site.
論文 | ランダム
- 給人多久氏夫妻と知行地入部--武家の妻と主従制・領主制 (特集 佐賀藩多久領と周辺の諸問題)
- 給人領主の知行地「御下」について--佐賀藩神代鍋島氏を素材に
- 知行地の年中行事--佐賀藩神代鍋島氏の「日記」を中心に
- 公設事務所だより「津々浦々にひまわりの花を」(第87回)小浜ひまわり基金法律事務所
- 海洋性コレステロールの特徴と皮膚・毛髪への効果 (特集 香粧品の新原料・新技術)