A New Series of 2-Alkoxy(aralkoxy)-[1,2,4]triazolo[1,5-a]quinazolin-5-ones as Adenosine Receptor Antagonists
スポンサーリンク
概要
- 論文の詳細を見る
This research was carried out to study the pharmacological activity of a newly synthesized series of 2-alkoxy-[1,2,4]triazolo[1,5-a]quinazolin-5-ones as adenosine receptor antagonists. These compounds have been tested in radioligand binding assays on cloned Chinese hamster ovary (CHO) cells transfected with A1, A2A, A2B and A3 receptors. In particular, among the triazoloquinazolines (1—11), the dialkoxy derivative (7b) was found to have the highest affinity at A1 subtype receptor, and its radioligand binding activity together with 1,3-dipropyl-8-cyclopentylxanthine (DPCPX) was studied. Finally, the structure–activity relationship (SAR) studies on the titled compounds provide some new insights about steric hindrance and lipophilic requirements for anchoring to the adenosine receptors recognition site.
論文 | ランダム
- ロシア支援を無効にする資本逃避--カネやモノを注ぎ込む前にやるべきことは多い
- 我孫子丸刈り狂騒曲--発端から強制の廃止まで
- SOCIETY & THE ARTS インタビュー アジア女性=***の幻想
- ゲルツェンとロシヤ自由主義者--「皇帝アレクサンドル二世への手紙」をめぐって (早稲田大学創立百周年記念)
- 特別レポ-ト 個人金融資産1200兆円と地域金融機関のビッグバン対応