イブプロフェンマイクロスフェアーを用いたサスペンジョン型経口徐放剤の薬物放出特性と生物学的利用能
スポンサーリンク
概要
- 論文の詳細を見る
The drug release behavior and bioavailability of newly developed controlled release suspensions of ibuprofen were investigated. The suspension was prepared by suspending spherical matrices(particle diameter 350-800 <I>μ</I>m) of the drug with acrylic polymer in aqueous media containing sodium carboxymethylcellulose and D-sorbitol whose pH was adjusted below 3.0. The drug release behavior of suspension precisely followed to that of original spherical matrix, suggesting little leakage of the drug from the suspended matrices during storage, The bioavailability of rapid drug release suspensions administrated orally was determined by the initial drug release rate of the suspended matrices <I>in vitro</I> dissolution test. Whereas the bioavailability of sustained drug release suspension orally administrated depended on the particle sires of suspended matrices, even with same drug release behavior <I>in vitro</I>. Finally, twice a day regimen was successfully achieved by administering orally 225.0 mg of the sustained release matrices suspended to beagle dogs.
論文 | ランダム
- 104 シングルショットピーニングとダブルショットピーニングを施した鋼ローラの面圧強さ(OS02-1 歯車の強度I)
- 1001 ショットピーニングを施した粉末鍛造ローラの面圧強さ(機素潤滑設計III)
- 耕作放棄地の現状と対策
- 911 ダブルショットピーニングを施した鋼ローラの面圧強さに関する基礎的研究(機素潤滑設計I)
- 高等専門学校男子学生の生活習慣および健康状態の縦断的推移--3年間の縦断的資料を用いて