7%炭酸水素ナトリウム液添加によるアクラルビシン・リピオドール溶液を用いたoil-chemo-embolizationの基礎的検討 :
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概要
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Water soluble aclalubicin hydrochloride(ACR, Aclacinone<SUP>®</SUP>, Yamanouchi Pharmaceutical Comp. Japan) was dissolued into Lipiodol Ultra-Fluid<SUP>®</SUP>(Kodama Co. Ltd. Japan) with an addition of an equivalent amount of 7% sodium bicarbonate (Meylon<SUP>®</SUP>, Otuska Pharm. Co. Ltd. Japan). A maximum concentration of ACR in LPD reached to approximately 20 mg/m<I>l</I>. Release of ACR from ACR/LPD solution was documented for more than 6 weeks period. Intraarterial infusion of ACR/LPD (1.5 mg/0.1 m<I>l</I>/kg) reduced tumor growth significantly(P<0.01-0.05)in rabbit VX-2 hepatoma model comparing to groups they received ACR/H<SUB>2</SUB> O solution (ACR 1 mg/kg, 1.5 mg/kg), LPD alone(0.1 m<I>l</I>/kg), and ACR/LPD (1.0 mg/0.1 mg/kg). These results suggest that the ACR/LPD solution with 7% sodium bicarbonate may be an active agent for intraarterial targeting chemotherapy which has delayed releasing of ACR.
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