活性炭吸着ペプロマイシンの皮下投与における急性毒性の病理組織学的検討

概要

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A new dosage formulation (PEP-CH) composed of activated carbon particles adsorbing peplomycin, was examined for its macroscopic and microscopic pathological effects of subcutaneous adminstration in mice. Both formulations of PEP-CH and peplomycin aqueous solution (PEP-SOL) decreased the organ weights and the relative organ weights (organ weight/body weight) of the kidney and the spleen. These two formulations caused histological damages of the renal tubules and atrophy in the spleen and the thymus. Macroscopic and microscopic examination found no pathological changes in the lung exept for the slight congestion. There were no differences between these two formulations in the autopsy findings.