ニワトリの視床下部内局所注入のノルアドレナリンおよびセロトニンの盲腸運動に及ぼす作用〔英文〕
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An attempt was made to study how noradrenaline (NA) and serotonin (5-hydroxytryptamine, 5-HT) injected locally into the hypothalamus of chickens acted on the motility of the cecum, and to elucidate the functional relationship between the hypothalamus and the adrenergic receptors distributed in the cecum.The following results were obtained.1. Facilitation of motility and an increase in tonus of the cecum were noted in chickens injected locally with 20μg of 5-HT into the nucleus (nucl.) hypothalamicus anterior medialis, nucl. paraventricularis magnocellularis, nucl. preopticus medialis and decussatio supraoptica dorsalis in the anterior hypothalamus. These responses to the application of 5-HT were immediate excitatory ones.Application of 40μg of NA to the nucl. hypothalamicus anterior medialis and decussatio supraoptica dorsalis in the hypothalamus resulted in inhibition of cecal motility. Application of 40μg of NA to the nucl. hypothalamicus lateralis and natl. hypothalamicus posterior medialis in the posterior hypothalamus caused a transient inhibition of cecal motility followed by facilitation. Application of 20μg of 5-HT to these two nuclei induced inhibition of contraction of the cecum. The response to the application of NA was a delayed excitatory one preceded bo an inhibitory phase.All these responses may probably present a difference in activation pattern between the NA-sensitive and 5-HT-sensitive areas.2. A transient inhibition of cecal motility which followed the facilitation, and which appeared after the application of NA to the posterior hypothalamus may have been brought about by intermediary of α-and β-adrenergic receptors in the cecum. Facilitation by the former and inhibition by the latter were suggested.
- 社団法人 日本畜産学会の論文