絶食動物における血糖量の維持とグルココルチコイド〔英文〕

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Changes of blood glucose, protein and lipid levels during fasting in sheep and rats, and the effects of intravenously injected glucose on plasma 11-OHCS, protein and lipid levels were studied in the fasting sheep. In both species, blood glucose level decreased for the first few days (P<0.05), then remained at a low level and finally showed a slight rebound. During fasting period plasma total protein level continued to increase up to 10 days in sheep (P<0.01), while it began to decrease on the 4th day of fasting in rats where decrease was significant only in the female on the 6th day (P<0.05). Changes in plasma total lipid level with the progress of fasting were similar to that of protein in both species. In sheep, major changes in lipids were found in the free fatty acid fraction (FFA) (P<0.01). Intravenous injection of glucose into the fasting sheep caused marked decreases in levels of plasma 11-OHCS (P<.01), total plasma protein (P<.01), total lipids (P<0.05) and FFA (P<0.01). Clear reciprocal changes found between levels of circulating 11-OHCS and blood glucose in the fasting sheep suggested that glucocorticoids seem to play an important role for the regulation of blood glucose in this species.
公益社団法人日本畜産学会の論文