めん羊におけるメトヘモグロビン形成時の肝臓機能について
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概要
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In order to understand nitrate poisoning status of ruminants, the authors undertook the experiment on liver function of sheep by using bromsulfalein reagent under different methemoglobin formation in blood. Initial liver function of all animals was known to be in normal ranges, since serum BSP residue for seven animals (30min. after injection) were less than 5%. When hemoglobin was converted to methemoglobin in blood after intraruminal administration of nitrite, BSP clearance rate began to decrease. It showed that methemoglobin formation in blood seemed to depress some liver function of the animals. A highly significant correlation (r=0.937, P<0.001 for 15min. value, r=0.903, P<0.001 for 30min. value) between BSP residue value in serum and methemoglobin content in blood was found from the combined data for all animals. Especially, depression of liver function was remarkable when methemoglobin content in blood exceeded 35% of total hemoglobin, since BSP residue (30min. value) of more than 5% was known to be a critical level for depressed liver function. However, when methemoglobin content decreased in blood, BSP residue in serum seemed to decrease. Therefore, depressed clearance rate of BSP by methemoglobin formation seemed to be rapid but temporary.
- 公益社団法人 日本畜産学会の論文
公益社団法人 日本畜産学会 | 論文
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