神経軸索輸送

概要

論文の詳細を見る
Three main approaches are commonly used in dectecting axonal transport; (a) accumulation of substances in dammed nerves; (b) direct observation of the movement of organelles in nerves; and (c) transport of radioactive substances along nerves. Most phenomena of axonal transport are classified into three types; (a) slow anterograde; (b) fast anterograde; (c) fast retrograde. phases. Pressure injection technique to introduce radioactive substances into some exceptionally large cell bodies in Aplysia neurones is useful because the study of transmitter specificity can be realyzed in an identified neurone. Some hypothetical models of axonal transport machinery were introduced. Recent progress of axonal transport was described from biophysical point of view. One is application of modern radiation detectors for measurement of tracer profiles in neurones, such as semiconducter detector and multiwire proportional chamber. The second is artificial cell model such as skinned axon and introduction of artificial panticles which simulate transported vesicles. The third is theoretical studies of axonal transport; time dependent tracer profiles were simulated by using a digital computer. Some physiological significance of axonal transport was also discussed.
日本生物物理学会の論文