シナプスの可塑性
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Recent morphological and histochemical studies showed that the neuronal connections in the central nervous system of adult mammals show more flexibility than has been considered before. Partial denervation, for example, often causes sprouting from the remaining intact axons.<BR>Our electrophysiological studies on the neurons of red nucleus (RN) of adult cats revealed that elimination of interposito-rubral input which impinge upon somatic portion induces collateral sprouting and synapse-formation of fibers from sensori-motor cortex of the cerebellum. The neurons in the sensori-motor cortex, which normally make connections on the distal dendrite of the RN cell, made new connections on the proximal dendrite after lesion of interpositus nucleus. The newly-formed synapses were functionally effective and had similar properties of synaptic transmission.<BR>Collateral sprouting from cortico-rubral fibers also occurs after cross-union of the nerves innervating the forelimb flexor and extensor nerves of adult cats. This sprouting was restricted to the RN neurons innervating the forelimb and was considered to be a consequence of the operation of cross-union.<BR>Causes that induces sprouting was discussed in relation to above results and other experiments on neuromuscular synapse-formation.
- 日本生物物理学会の論文