ミオグロビン・ヘモグロビンの自動酸化反応
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概要
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The stability properties of the iron (II)-dioxygen bond in Mb and Hb are of particular importance, since the oxygenated form is known to be oxidized easily to the ferric met-form, which cannot be oxygenated and is therefore physiologically inactive. Since the early work of the 1930s, it has been observed that the autoxidation rate increases with decreasing partial pressure of O2 and increases with increasing H<SUP>+</SUP> concentration. Several proposals have therefore been made concerning the mechanism of this autoxidation reaction, and these can be classified into the following three types: (a) Oxidation, (b) Dissociation, and (c) Displacement.<BR>These provide an interesting basis not only for future study, but also for a full understanding of general principles governing molecular oxygen enzymology including oxygenases and oxidases.