Physiopathological function of hematoside (GM3 ganglioside)

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概要

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• Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3. During the course of study, we demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in membrane microdomains and propose a new concept: Life style-related diseases, such as type 2 diabetes, are a membrane microdomain disorder caused by aberrant expression of gangliosides. We also encountered an another interesting aspect indicating the indispensable role of gangliosides in auditory system. After careful behavioral examinations of SAT-I knockout mice, their hearing ability was seriously impaired with selective degeneration of the stereocilia of hair cells in the organ of Corti. This is the first observation demonstrating a direct link between gangliosides and hearing functions.(Communicated by Kunihiko SUZUKI, M.J.A.)

著者

• Inokuchi Jin-ichi

  Division Of Glycopathology And Crest Japan Science And Technology Agency Institute Of Molecular Biom

• INOKUCHI Jin-ichi

  Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University

関連論文

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• 膜マイクロドメインにおける成長因子受容体の制御
• Physiopathological function of hematoside (GM3 ganglioside)
• Insulin Resistance as a Membrane Microdomain Disorder(Symposium Review)

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