Repeated Intracoronary Infusion of Peripheral Blood Stem Cells With G-CSF in Patients With Refractory Ischemic Heart Failure : – A Pilot Study –
スポンサーリンク
概要
- 論文の詳細を見る
Background: Recent investigations have suggested the clinical efficacy of granulocyte colony-stimulating factor (G-CSF) infusion alone or in combination with a single dose delivery of peripheral blood stem cells (PBSC) infusion in patients with myocardial infarction (MI) and congestive heart failure (HF). The current study tested the feasibility and effect of repeated intracoronary infusions PBSC and the mobilization of G-CSF in patients with refractory HF after MI. Methods and Results: Patients with recent large MI and a lower left ventricular ejection fraction (LVEF) were enrolled into one of the following 3 groups: Group R (n=15) received repeated intracoronary infusion of PBSC and one-dose of G-CSF; Group S (n=15) received a single infusion of PBSC and a G-CSF dose; and Group C (n=15) received neither PBSC nor a G-CSF dose. Cardiac performance was evaluated by echocardiography and single photon-emission computed tomography (SPECT). All the patients underwent 12-month follow-up. LVEF in Group R (47.00±4.90%) was significantly higher than that in Group S (44.40±3.87%, P<0.01) and Group C (40.80±3.41%, P<0.01). Similarly, the improvement of myocardial perfusion assessed by SPECT in Group R was more than that in Group S (P=0.012) and Group C (P<0.01). Neither death nor new MI occurred. Conclusions: Repeated intracoronary infusions of PBSC plus mobilization of G-CSF might be an optional effective strategy for treating patients with refractory HF after recent large MI. (Circ J 2011; 75: 955-963)
論文 | ランダム
- マイクロファイパースコープを用いた経気管支擦過細胞診の試み : 気管支鏡
- pN_2肺非小細胞癌におけるsN_0、_1症例とsN_2症例の予後比較 : 予後因子(8)
- 7. 極細径気管支ファイバースコープを用いた肺気腫症例における末梢気管支の観察(第 69 回 日本気管支学会関東支部会)
- 114. 喀痰細胞診陽性でフォローアップを要した症例の検討(呼吸器I)(第35回日本臨床細胞学会総会学術集会)
- 1.気管支扁平上皮化生に対する葉酸およびビタミンB_の併用効果の臨床的検討 : 第45回大会シンポジウム(ビタミン・バイオファクターと発癌制御)