Characterization and Distribution of an Arginine Vasotocin Receptor in Mouse
スポンサーリンク
概要
- 論文の詳細を見る
A cDNA, which has a high homology with teleost Platichthys flesus [Arg8] vasotocin (AVT) receptor (GenBank: AK033957), was found in mouse genome database. Analyses of the deduced amino acid sequence revealed that a cDNA has several features of AVT receptor. We tentatively named it as a mouse vasotocin receptor (MVTR). A two-electrodes voltage clamp technique was applied to characterize the MVTR expressed in Xenopus laevis oocytes. AVT induced Ca2+-dependent Cl- currents in Xenopus oocytes injected with MVTR cRNA. On the other hand, [Arg8] vasopressin, oxytocin and isotocin did not induce such currents. RT-PCR showed that MVTR mRNA was specifically expressed in the brain. In situ hybridization analysis demonstrated significant expression of MVTR mRNA in suprachiasmatic nucleus, arcuate nucleus and medial habenular nucleus of mouse brain. These results suggest that MVTR may mediate a variety of physiological functions in mouse.
論文 | ランダム
- 慢性肝障害回復期における肝結合織成分の変動について
- 読み切り 新潟豪雨災害 時間の経過とともに深刻となる高齢者のくらし
- 慢性肝疾患における血中および肝組織内オーストラリア抗原と血中抗オーストラリア抗体について
- 統合失調症の高齢化による諸問題--高齢化に伴う病態の変化,認知症との相違について (第38回日本精神科病院協会精神医学会 魅力あふれる精神科医療の実践--変わりゆく社会の中で私たちの果たす役割) -- (シンポジウム 統合失調症患者の高齢化による諸問題)
- 生分解性プラスチックスのル-ツ