Chronic exposure to arsenite induces S100A8 and S100A9 expression in rat RBL-2H3 mast cells
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the effects of chronic exposure to arsenite on the gene expression profiles of mast cells, microarray analysis was performed on rat basophilic leukemia RBL-2H3 cells exposed to arsenite for 28 days. Upregulated genes include calcium-binding S100 proteins such as S100A9, S100A10, S100A6, and S100A13, and granzymes B and C. Among S100 proteins, S100A9 showed the highest expression (8.62-fold of untreated cells) after 4-weeks of exposure to arsenite. As S100A8 and S100A9 comprise a heterodimer called calprotectin, and are implicated in the development of atherosclerosis and cancer, mRNA levels of both S100A8 and S100A9 were analyzed. The results demonstrated that exposure of RBL-2H3 cells to arsenite for a few weeks induces marked increases in mRNA levels of S100A8 and S100A9.
論文 | ランダム
- 戦後史における進歩と反動 (反動化に抗する)
- 国民分断のなかでの政治の回生--国家論のすすめ (日本ナショナリズムの現在)
- 現代における新聞の条件 (新聞へ)
- 資料館デジタルミュージアムシステムの構築
- 会議支援機能をもつ電子フォーラムの試作