Pulse Radiolysis Study on Free Radical Scavenger Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one). 2: A Comparative Study on Edaravone Derivatives
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概要
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A comparative study using the pulse radiolysis technique was carried out to investigate transient absorption spectra and rate constants for the reactions of •OH and N3• with edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) and its four analogue compounds, 1,3-dimethyl-2-pyrazolin-5-one, 3-methyl-1-(pyridin-2-yl)-2-pyrazolin-5-one, 1-phenyl-3-trifluoromethyl-2-pyrazolin-5-one and 1-(4-chlorophenyl)-3-methyl-2-pyrazolin-5-one. The results showed that, unlike reaction mechanisms previously proposed, the phenyl group of edaravone played an important role in the reaction with •OH and OH adducts to the phenyl group were formed. Quantum chemical calculations also strongly supported this attribution and suggested that the most favorable site for attacks by •OH is the ortho position of the phenyl group. Moreover, the rate constants for the reactions of edaravone and its analogues towards •OH and N3• were about 8.0 × 109, and 4.0 × 109 dm3 mol–1 s–1, respectively. Edaravone displayed higher reactivity compared to the others, in contrast to a previous report in which 3-methyl-1-(pyridin-2-yl)-2-pyrazolin-5-one showed the highest reactivity towards •OH.
著者
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Yoshioka Katsuji
Nuclear Engineering Research Laboratory Graduate School Of Engineering The University Of Tokyo
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FU Haiying
Nuclear Professional School, School of Engineering, The University of Tokyo
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HATA Kuniki
Nuclear Professional School, School of Engineering, The University of Tokyo
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MUROYA Yusa
Nuclear Professional School, School of Engineering, The University of Tokyo
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Fu Haiying
Nuclear Professional School School Of Engineering The University Of Tokyo
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KATSUMURA Yosuke
Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo
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Muroya Yusa
Nuclear Engineering Research Laboratory Graduated School Of Engineering University Of Tokyo
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Lin Mingzhang
Nuclear Engineering Laboratory School Of Engineering University Of Tokyo
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HATA Kuniki
Department of Nuclear Engineering and Management, School of Engineering, The University of Tokyo
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FU Haiying
Radiation Chemistry and Technology Laboratory, Shanghai Institute of Applied Physics, Chinese Academ
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YAMASHITA Shinichi
Advanced Science Research Center, Japan Atomic Energy Agency
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NAKAGAWA Hidehiko
Graduate School of Pharmaceutical Sciences, Nagoya City University
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Fu Haiying
Radiation Chemistry And Technology Laboratory Shanghai Institute Of Applied Physics Chinese Academy
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Nakagawa Hidehiko
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Yamashita Shinichi
Advanced Science Research Center Japan Atomic Energy Agency
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Hata Kuniki
Department Of Nuclear Engineering And Management School Of Engineering The University Of Tokyo
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Lin Mingzhang
Nuclear Science And Engineering Directorate Japan Atomic Energy Agency
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Katsumura Yosuke
Department Of Nuclear Engineering And Management Graduate School Of Engineering University Of Tokyo
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