中脳ドーパミン細胞における形態発達の特徴と受動的膜モデルの一構成法

概要

論文の詳細を見る
In this study, I aim to understand morphological changes in dopaminergic neurons of the rat midbrain during early developmental stages and their computational properties in the dendrites. To this end, firstly, I measured morphological details of dopaminergic neurons using an immunochemical double-staining technique. In the viewpoint of the Ralls equivalent-cylinder model, secondly, I tested if the data satisfied one of conditions (3/2 power law) of the Ralls model. On the basis of the experimental data, I next investigated if some branches in the individual dendrites had special selectivity in efficient passive propagation of membrane potentials between the branches of individual cells and different cells. The results show that the Ralls 3/2 power law was not satisfied in many branch points and that among branches of each dendrite, specific selectivity in efficient propagation was not found. In addition, I note an implementation method in which the finite element method is applied to one-dimensional cable model of dendrites and give some numerical examples.