Desensitization Therapy for Allergic Reactions to Antituberculous Drugs
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概要
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Objective We retrospectively evaluated the clinical usefulness of desensitization therapy for many patients showing allergic reactions to anti-mycobacterial drugs (INH and RFP) according to the proposition reported by the Japanese Society for Tuberculosis (JST). Methods Desensitization therapy for anti-mycobacterial drugs was performed according to the propositions of JST for forty-six patients with mycobacterial disease in several hospitals partcipating in the Chugoku-Shikoku Mycobacterial Disease Committee between January 1999 and December 2009. Results Adverse reactions occurred as drug-induced skin eruptions in 23 patients, drug-induced fever in 16, and drug-induced fever plus eruption in 7. The causative drugs suggested by the clinical course or DLST were RFP in 30 patients and INH in 16. The clinical effects of desensitization therapy for individual drugs was good in 23 of 30 patients (77%) receiving RFP, and in 13 of 16 (81%) receiving INH. Ten patients showing failure of desensitization included 5 elderly patients and 2 patients with a history of drug allergies. The interval until initiation of desensitization therapy ranged from 5 to 30 days after the disappearance of adverse reactions and the interval until the appearance of adverse reactions during desensitization therapy ranged from 3 to 18 days. A comparative study between the patient group with successful desensitization therapy and that with failure of desensitization did not show any significant differences except for the interval until initiation of desensitization therapy. Conclusion We confirmed the clinical effectiveness of desensitization therapy for anti-mycobacterial drugs according to the propositions of JST in this multicenter study.
論文 | ランダム
- 社会的ジレンマ事態における集団行動--集団間関係の研究法としてのSIMSOCの導入 (集団とその環境)
- 社会的ジレンマの数理的研究法に関する研究会(研究会報告)
- 社会的ジレンマ状況での非協力から協力への行動変容--バイク駐車行動のフィ-ルドスタディによる態度-行動の一貫性の検討
- 社会的ジレンマ研究者の環境問題
- 社会的ジレンマにおける行動の時系列的分析