Anti-hyperuricemic Effect of Fermented Barley Extract is Associated with Increased Urinary Uric Acid Excretion
スポンサーリンク
概要
- 論文の詳細を見る
Effects of a fermented barley extract P (FBEP) on uric acid (UA) metabolism in three hyperuricemia rat models were studied. First, the influence of FBEP on UA biosynthesis was examined using rats hypodermically administrated oxonic acid. Then, the influence of FBEP on dietary purine absorption was examined using rats fed a high dose of inosinic acid. Finally, the influence of FBEP on UA excretion was examined using adenine-administered rats. From the first two models, FBEP was found to be rarely, or not at all, involved in the biosynthesis of UA or absorption of nucleic acid. On the other hand, in the rats loaded with adenine, it was shown that the urinary UA of the high-dose FBEP group (4,000 mg/kg/day) was significantly elevated by 27% compared to the control group. In addition, the UA clearance value in the high-dose FBEP group was increased 2-fold compared to the control group. These results suggest that FBEP reduces serum UA by increasing urinary excretion of UA.
論文 | ランダム
- ピエゾ電気収着法による溶融状態のポリイソブチレン中へのベンゼンとシクロヘキサンの溶解度の測定並びに修正二重収着モデルによる相関
- 慢性蕁麻疹,多形慢性痒疹におけるHelicobacter pylori菌の関与の検討(第1報)除菌治療の有効性
- 結節性多発動脈炎 : 皮膚型の位置づけをふまえ
- JSY-3 声門下狭窄に対するTチューブ挿入法の工夫(声門下狭窄の治療方針,日本気管食道科学会との合同企画,ジョイントシンポジウム,第34回日本呼吸器内視鏡学会学術集会)
- PS-199-3 大腸癌の異時性腹膜播種再発に対する切除例の検討(PS-199 ポスターセッション(199)大腸:手術-8,第111回日本外科学会定期学術集会)